- Born in 1522 in Alba de Tormes
- Deceased on December 17, 1562 in Pisa, at the approximate age of 39 years
Parents
- Pedro Álvarez de Toledo (1484 - 1553), vice-roi de Naples
- Maria Pimentel, marquesa de Villafranca del Bierzo
Family
- Married on May 14, 1539 in Florence, with Cosimo de' Medici, Cosme Ier de Toscane (1519 - 1574), Grand-duc de Toscane, issuing
Francesco (1541 - 1587)- Isabella (1542 - 1576)
- Giovanni di Cosimo (1543 - 1562)
- Lucrezia (1545 - 1561)
- Pietro (1546 - 1547)
- Antonio (1548 - 1548)
- Ferdinando (1549 - 1609)
- Anna (1553 - 1553)
- Pietro (1554 - 1604)