- Born on November 22, 1515 in Bar-le-Duc
- Baptized on December 2, 1515
- Deceased on June 10, 1560 at Edinburgh Castle, at the age of 44 years
- Burial in 1560 in Reims
Parents
- Claude de Lorraine, Claude de Guise (1496 - 1550), chevalier, duc de Guise, pair de France
- Antoinette de Bourbon-Vendôme (1494 - 1583), duchesse de Guise
Family
- Married on August 4, 1534 in Paris, with Louis II d'Orléans-Longueville (1510 - 1536), duc de Longueville, issuing
François III (1535 - 1551)- Louis (1536 - 1536)
- Married on June 12, 1538 in Saint Andrews, with James Stewart, James V of Scotland (1512 - 1542), King of Scotland, issuing
- Mary (1542 - 1587)