- Born in 1440
- Assassinated on May 31, 1488, at the approximate age of 47 years
Parents
- Astorre II Manfredi (1412 - 1468), signore di Imola
- Giovanna da Barbiano
Family
- Relationship with Cassandra Pavoni, Suor Benedetta ( - 1513), issuing
- Francesco (1470 - 1509)
- Scipione (1473 - 1493)
- Giovanni Evangelista (1482 - 1502)
- Married on February 17, 1482, with Francesca Bentivoglio (1468 - 1504), issuing
- Astorre III (1485 - 1502)