- Born on April 2, 1514 at Palazzo Ducale di Urbino
- Deceased on September 28, 1574 at Palazzo Ducale di Pesaro, at the age of 60 years
Parents
- Francesco Maria I della Rovere (1490 - 1538), duca di Urbino, préfet de Rome 24, capitaine général de l'Eglise 24
- Eleonora Gonzaga (1493 - 1550), principessa di Mantova
Family
- Married in 1534, with Giulia Varano (1523 - 1547), duchessa di Camerino, issuing
Virginia (1544 - 1571)
- Married with Caterina Ristori, issuing
- Camilla (1537 - 1591)
- Relationship with Cassandra de Ricci, issuing
- Felice (1547 - 1621)
- Married on July 9, 1547, with Vittoria Farnese (1519 - 1602), issuing
- Francesco Maria II (1549 - 1631)
- Giovanni Pietro (1551 - 1554)
- Eleonora (1552 - 1553)
- Costanza (1553 - 1553)
- Isabella (1554 - 1619)
- Alessandro (1556 - 1556)
- Federico (1557 - 1570)
- Lavinia Feltria (1558 - 1632)
- Vittoria (1561 - 1566)