Married on June 14, 1557, with Jean de Bourbon-Vendôme (1528 - 1557), duc d'Estouteville, capitaine de cinquante lances des ordonnances, without issue.
Married on October 1, 1560, with François Ier de Clèves (1516 - 1562), duc de Clèves, gouverneur de Champagne et de Brie, pair de France, without issue.
Married on July 2, 1563, with Léonor d'Orléans-Longueville (1540 - 1573), prince de Neuchâtel, grand chambellan de France, pair de France, issuing